Natural killer cells and natural killer T cells in Lyme arthritis
نویسندگان
چکیده
منابع مشابه
Natural killer cells and natural killer T cells in Lyme arthritis
NK cells are important in protecting against viral infections, and they may regulate the immune response. They are activated by hematopoietic blasts and pose a barrier to bone marrow transplantation. They are also abundant in the pregnant uterine decidua, although their role there is unknown. NK cells are normally inhibited from responding to host cells by inhibitory receptors that recognize se...
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Invariant Natural killer T cell (iNKT cells) are a subset of T cells, which are narrowly defined as a T cell lineage expressing a semi-invariant CD1d-restricted T cell Receptors (TCRs) composed by Vα24-Jα18/Vβ11 in human, and Vα14-Jα18/Vβ8,Vβ7, and Vβ2 in mouse. Unlike conventional T cells which recognize peptides bound to highly polymorphic major histocompatibility complex (MHC) class I and II...
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α-GalCer = α-galactosylceramide, MHC = major histocompatibility complex, NKT = natural killer T cell, RA = rheumatoid arthritis, TCR = T cell receptor, Th = T helper. Natural Killer T (NKT) cells have been described as T lymphocytes expressing NK receptors such as NK1.1. This lymphocyte subset consists of several subpopu-lations, each with distinct characteristics [1, 2]. Unlike conventional T ...
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ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2013
ISSN: 1478-6354
DOI: 10.1186/ar4373